Propionic Acid Calcium Potassium Sodium Propionate Manufacturers

Anmol Chemicals is the pioneer manufacturers of Propionic acid, Calcium Potassium Sodium Propionate, Pharmaceutical Excipients Food & Flavor chemicals in India. We offer Halal and Kosher Propionic acid, Calcium Potassium Sodium Propionate made in an ISO9001, ISO22000 (FSSC22000) cGMP and GLP certified facility. Our group has several manufacturing facilities spread across the world, supported by toll manufacturers and representatives in UAE, Europe, USA, China and has several associated manufacturing facilities spread across India. All the Information on Physics, Chemistry, Applications, Uses and Technology on Manufacture of Propionic acid, Calcium Potassium Sodium Propionate is in these pages.

The units have one or more of the certifications like FDA GMP, ISO 9001, ISO 22000, HACCP, REACH, Kosher & Halal

Propionic Acid USP FCC Food Grade Calcium Potassium Sodium Propionate Manufacturers

Propionic Acid CAS Number 79-09-4, EINECS EC Number 201-176-3, HS Code ---**; Molecular Weight CH3CH2COOH, Molecular Formula: 74.08

Calcium Propionate CAS number 4075-81-4; EINECS EC number 223-795-8, HS Code: 291550**, Molecular formula C6H10CaO4; Molecular Weight 186.22

Potassium Propionate CAS Number 327-62-8, EINECS EC Number: 206-323-5, Molecular Formula: CH3CH2COO-K+, Molecular Weight: 112.17

Sodium Propionate CAS Number 137-40-6, EINECS EC Number 205-290-4, HS Code 291550**, Molecular Weight 96.06, Chemical Formula CH3CH2COONa

Propionic acid 3CH2COOH is a naturally occurring carboxylic acid. It is a clear liquid with a pungent and unpleasant smell somewhat resembling body odor. The anion CH3CH2COO− as well as the salts and esters of propionic acid are known as propionates (or propanoates).

Propionic Acid USP NF Grade
Propionic Acid contains not less than 99.5 percent and not more than 100.5 percent, by weight, of C3H6O2.
Specific gravity: between 0.988 and 0.993.
Distilling range: between 138.5 and 142.5 .
Heavy metals: To the residue obtained in the test for Nonvolatile residue add 8 mL of 0.1 N hydrochloric acid, warm gently until solution is complete, dilute with water to 100 mL, and use 10 mL of the solution: the limit is 0.001%.
Limit of nonvolatile residue: Evaporate 20 g in a tared dish, and dry at 105 for 1 hour: the weight of the residue does not exceed 2.0 mg.
Readily oxidizable substances: Dissolve 15 g of sodium hydroxide in 50 mL of water, cool, add 6 mL of bromine, stirring to effect complete solution, and dilute with water to 2000 mL. Transfer 25.0 mL of this solution to a glass-stoppered, 250-mL conical flask containing 100 mL of water, and add 10 mL of sodium acetate solution (1 in 5) and 10.0 mL of Propionic Acid. Allow to stand for 15 minutes, add 5 mL of potassium iodide solution (1 in 4) and 10 mL of hydrochloric acid, and titrate with 0.1 N sodium thiosulfate VS just to the disappearance of the brown color. Perform a blank determination. The difference between the volume of 0.1 N sodium thiosulfate required for the blank and that required for the test specimen is not more than 2.2 mL.
Limit of aldehydes: Transfer 10.0 mL to a glass-stoppered, 250-mL conical flask containing 50 mL of water and 10.0 mL of sodium bisulfite solution (1 in 80), insert the stopper, and shake vigorously. Allow the mixture to stand for 30 minutes, then titrate with 0.1 N iodine to the same brownish yellow endpoint obtained with a blank treated with the same quantities of the same reagents. The difference between the volume of 0.1 N iodine required for the blank and that required for the test specimen is not more than 1.75 mL.
Assay: Mix about 1.5 g of Propionic Acid, accurately weighed, with 100 mL of recently boiled and cooled water in a 250-mL conical flask, add phenolphthalein, and titrate with 0.5 N sodium hydroxide to the first appearance of a faint pink endpoint that persists for not less than 30 seconds.

Propionic Acid FCC Food Grade
CH3CH2COOH
C3H6O2 Formula wt 74.08
INS: 280 CAS: [79-09-4]

DESCRIPTION
Propionic Acid occurs as an oily liquid. It is miscible with water, with alcohol, and with various other organic solvents.
Function: Preservative; mold inhibitor.

Calcium Propionate, (CH3CH2COO)2Ca, is an effective inhibitor of the growth of certain moulds and some bacteria and it is applied as a preservative in dairy products. It is listed as a food additive with E number 282. Calcium propanoate is used as a preservative in a wide variety of products, including bread, other baked goods, processed meat, whey, and other dairy products. In agriculture, it is used, amongst other things, to prevent milk fever in cows and as a feed supplement. Calcium propanoate is used in bakery products as a mold inhibitor, typically at 0.1-0.4% (though animal feed may contain up to 1%). It also becomes a source of Calcium in such food products. It is also used as a fungicide on fruit.

Potassium propanoate or potassium propionate is used as a food preservative and is represented by E number E283 in Europe and by the INS number 283 in Australia and New Zealand. Propionates prevent microbes growth like benzoates do. However, unlike benzoates, propionates do not require an acidic environment. Potassium propionate is used in bakery products as a mold inhibitor, typically at 0.1-0.4%.

Sodium Propionate BP Ph Eur Grade Specifications
C3H5NaO2
96.1 -- 137-40-6
Action and use: Antifungal

DEFINITION
Sodium propionate
Content: 99.0 per cent to 101.0 per cent Sodium propionate (dried substance).

CHARACTERS
Appearance: Colourless crystals or, white or almost white powder, slightly hygroscopic.
Solubility: Freely soluble in water, sparingly soluble in alcohol, practically insoluble in methylene chloride.

IDENTIFICATION
First identification A, D.
Second identification B, C, D.
A. Infrared absorption spectrophotometry.
Comparison reference spectrum of sodium propionate.
B. Dissolve 0.1 g in a mixture of 2 ml of copper sulphate solution and 2 ml of methylene chloride. Shake vigorously and allow to stand. Both the upper and the lower layer show a blue colour.
C. To 5 ml of solution S add 2 ml of 0.1 M silver nitrate. A white precipitate is formed.
D. Solution S gives reaction of sodium.

TESTS
Solution S: Dissolve 10 g Sodium propionate in carbon dioxide-free water prepared from distilled water and dilute to 100 ml with the same solvent.
Appearance of solution: Solution S is clear and colourless.
pH: 7.8 to 9.2
Dilute 1 ml of solution S to 5 ml with water.
Related substances: Liquid chromatography.
Test solution: Dissolve 0.250 g of the substance to be examined in water and dilute to 100 ml with the same solvent.
Reference solution (a) Dissolve 10 mg of the substance to be examined and 10 mg of sodium acetate in water and dilute to 100 ml with the same solvent.
Reference solution (b) Dilute 1.0 ml of the test solution to 100 ml with water.
Column: ı
ı— size: l= 0.25 m, Ø = 4.6 mm;
ı— stationary phase: octadecylsilyl silica gel for chromatography (5μm).
Mobile phase Dilute 1 ml of phosphoric acid R to 1000 ml with water.
Flow rateı1 ml/min.
Detection Spectrophotometer at 210 nm.
Injectionı20 μl.
System suitability Reference solution (a):
ı— resolution: minimum 5 between the peaks due to sodium acetate and sodium propionate.
Limits:
ı— any impurity: not more than 0.1 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.1 per cent);
ı— total: not more than half the area of the principal peak in the chromatogram obtained with reference solution (b) (0.5 per cent);
ı— disregard limit: 0.05 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.05 per cent).
Readily oxidizable substances:
In a ground-glass-stoppered conical flask introduce 10 g of the substance ( Sodium propionate.) to be examined.
Add 100 ml of water R and stir to dissolve. Add 25 ml of sodium hypobromite solution and 10 ml of a 200 g/l solution of sodium acetate, stopper the flask and allow to stand for 15 min. Add 10 ml of potassium iodide solution and 20 ml of hydrochloric acid while cooling.
Titrate with 0.2 M sodium thiosulphate, adding 2 ml of starch solution R towards the end of the titration. Carry out a blank titration. The difference between the volumes used in the 2 titrations is not greater than 2.2 ml.
Iron: Maximum 10 ppm.: 10 ml of solution S complies with the limit test for iron.
Heavy metals: Maximum 10 ppm.: 12 ml of solution S complies with limit test A. Prepare the standard using lead standard solution (1 ppm Pb).
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by heating in an oven at 105C for 3 h.

ASSAY
Dissolve 80.0 mg Sodium propionate in 30 ml of anhydrous acetic acid R. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically.
1 ml of 0.1 M perchloric acid is equivalent to 9.61 mg of C3H5NaO2.

Sodium Propionate FCC Food Grade Specifications
CH3CH2COONa
C3H5NaO2 Formula wt 96.06
INS: 281 CAS: [137-40-6]

DESCRIPTION
Sodium Propionate occurs as white or colorless, transparent crystals or as a granular, crystalline powder. It is hygroscopic in moist air. One gram is soluble in about 1 mL of water at 25°, in about 0.65 mL of boiling water, and in about 24 mL of alcohol. The pH of a 1:10 aqueous solution is between 8.0 and 10.5.
Function: Preservative; mold inhibitor.

REQUIREMENTS
Identification:
A. A 1:20 aqueous solution gives positive tests for Sodium.
B. Upon ignition, a sample yields an alkaline residue that effervesces with acids.
C. Warm a small sample with sulfuric acid. Propionic acid, recognized by its odor, evolves.
Assay: Not less than 99.0% and not more than 100.5% of C3H5NaO2 after drying.
Alkalinity (as Na2CO3): Passes test (about 0.15%).
Iron: Not more than 0.003%.
Lead: Not more than 2 mg/kg.
Water: Not more than 1%.

Sodium Propionate NF USP Grade Specifications
C3H5NaO2·xH2O
Propanoic acid, sodium salt, hydrate.
Sodium propionate hydrate [6700-17-0]
Anhydrous 96.06 [137-40-6]

Sodium Propionate, dried at 105 for 2 hours, contains not less than 99.0 percent and not more than 100.5 percent of C3H5NaO2.

Identification:
A: Infrared Absorption 197K , on un-dried specimen.
B: A solution (1 in 20) responds to the tests for Sodium.
Alkalinity: Dissolve 2.0 g in 20 mL of water, and add phenolphthalein TS: if a pink color is produced, it is discharged by 0.60 mL of 0.10 N sulfuric acid.
Water: not more than 1.0%.
Heavy metals: Dissolve 2 g in 1 mL of 1 N acetic acid and sufficient water to make 25 mL: the limit is 0.001%.
Assay: Dissolve about 200 mg of Sodium Propionate, previously dried at 105 for 2 hours and accurately weighed, in 50 mL of glacial acetic acid. Add 1 drop of crystal violet TS, and titrate with 0.1 N perchloric acid to a green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 9.606 mg of C3H5NaO2.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

Anmol Chemicals
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564. FAX: 91-22-23728264

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Name	Calcium Propionate
Appearance	White crystalline powder
Content % Dry basis assay	≥99.0
Moisture %	8-9 % (Can offer lower moisture)
Water insoluble matter %	≤0.15
Free acid￡¨as Propionic acid%	≤0.11
Free alkali as Sodium Hydroxide	≤0.06
Fluoride %	≤0.003
Mg %	≤0.4
Heavy metal as Pb %	≤0.001
Arsenic as As %	≤0.0002
pH	7.0 - 9.0

Test Name	Specifications
Description	Potassium Propionate is white or colorless crystalline powder.
Solubility	Soluble in water and ethanol
Identification	Positive test for Potassium and Propionate
pH	7.5 - 10.5
Loss on Drying	Not more than 4%
Water insoluble matter	Not more than 0.1%
Iron as Fe	Not more than 30 ppm
Lead as Pb	Not more than 5 ppm
Assay (as C3H5KO2 on dry basis)	Minimum 99%